When the Heart Affects the Mind: The Link Between Hypertension and Alzheimer’s
DOI:
https://doi.org/10.22201/ceide.16076079e.2026.27.3.2Keywords:
Hypertension, Alzheimer’s, Neurodegeneration, Tau protein, Beta-amyloid PeptideAbstract
High blood pressure and Alzheimer’s disease may seem unrelated at first, one affects the heart and blood vessels, the other memory and mental functions. However, recent scientific findings reveal a deeper connection between them. This article explores how elevated blood pressure, beyond its cardiovascular effects, can slowly harm the brain by creating an environment that favors the development of Alzheimer’s. It also delves into the physiological processes involved in both conditions and the relationship between them.
References
Alzheime’s Association. (2024). Alzheimer’s Association. Alzheimer’s dementia: the journal of the Alzheimer’s Association, 20(5), 3708-3821. https://doi.org/10.1002/alz.13809.
Busche, M. A., y Hyman, B. T. (2020). Synergy between amyloid-β and tau in Alzheimer’s disease. Nature neuroscience, 23(10), 1183-1193. https://doi.org/10.1038/s41593-020-0687-6.
Campos-Nonato, I., Hernández-Barrera, L., Oviedo-Solís, C., Ramírez-Villalobos, D., Hernández, B., y Barquera, S. (2021). Epidemiología de la hipertensión arterial en adultos mexicanos: diagnóstico, control y tendencias. Ensanut 2020. Salud Pública de México, 63(6), 692-704. https://tinyurl.com/yrc8vhzj.
Ferrari, C., y Sorbi, S. (2021). The complexity of Alzheimer’s disease: an evolving puzzle. Physiological reviews, 101(3), 1047-1081. https://doi.org/10.1152/physrev.00015.2020.
Ferreira Silva, M. V., Gomide Loures, C. M., Viera Alves, L. C., Cruz de Souza, L., Gomes Borges, K. B., y Carvalho, M. D. G. (2019). Alzheimer’s disease: risk factors and potentially protective measures. Journal of Biomedical Science, 26, 33. https://doi.org/10.1186/s12929-019-0524-y.
Harrison, D. G., Coffman, T. M., y Wilcox, C. S. (2021). Pathophysiology of Hypertension: The Mosaic Theory and Beyond. Circulation research, 128(7), 847-863. https://doi.org/10.1161/CIRCRESAHA.121.318082.
Lyon, M., Fullerton, J. L., Kennedy, S., y Work, L. M. (2024). Hypertension dementia: Pathophysiology potential utility of antihypertensives in reducing disease burden. Pharmacology therapeutics, 253, 108575. https://doi.org/10.1016/j.pharmthera.2023.108575.
Santisteban, M. M., Iadecola, C., y Carnevale, D. (2023). Hypertension, Neurovascular Dysfunction, and Cognitive Impairment. Hypertension, 80(1), 22-34. https://doi.org/10.1161/HYPERTENSIONAHA.122.18085.
Sinsky, J., Pichlerova, K., y Hanes, J. (2021). Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies. International Journal of Molecular Sciences, 22(17), 9207. https://doi.org/10.3390/ijms22179207.
Twarowski, B., y Herbet, M. (2023). Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review. International Journal of Molecular Sciences, 24(7), 6518. https://doi.org/10.3390/ijms24076518.
Wegmann, S., Biernat, J., y Mandelkow, E. (2021). A current view on Tau protein phosphorylation in Alzheimer’s disease. Current Opinion in Neurobiology, 69, 131-138. https://doi.org/10.1016/j.conb.2021.03.003.
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Himmelfarb, C. D., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., MacLaughlin, E. J., Muntner, P., Ovbiagele, B., Smith, S. C., Spencer, C. C., Stafford, R. S., Taler, S. J., Thomas, R. J., Williams, K. A., Williamson, J. D., y Wright, J. T. (2017). 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension, 71(6). https://doi.org/10.1161/hyp.0000000000000065.
Yao, Q., Jiang, K., Lin, F., Zhu, T., Khan, N. H., Jiang, E. (2023). Pathophysiological Association of Alzheimer’s Disease and Hypertension: A Clinical Concern for Elderly Population. Clinical Interventions in Aging, 18, 713-728. https://doi.org/10.2147/CIA.S400527.
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